Paving the way for designing drugs targeting TMEM16A

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 2021 English Publisher:Elsevier BVJournal:Trends in Pharmacological Sciences, volume 42, pages 979-980 (issn: 0165-6147,

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Authors: Simone Pifferi; Anna Menini;

doi: 10.1016/j.tips.2021.10.005

pmid: 34696895

Paving the way for designing drugs targeting TMEM16A

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Abstract

The calcium-activated chloride channel TMEM16A is involved in several physiological processes and is an important pharmacological target. Dinsdale and colleagues recently unveiled several residues in the outer pore region that constitute a critical site for the design of drugs that modulate TMEM16A channels.

Related Organizations

Marche Polytechnic University
Italy
International School for Advanced Studies
Italy

Keywords

Chloride Channels, Humans, Calcium, Anoctamin-1

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