Arresting Developments in Biased Signaling
Copyright policy )Arresting Developments in Biased Signaling
The ability to design 'biased' drugs that selectively activate G protein-coupled receptor (GPCR) signaling pathways beneficial in treating a disease, while limiting their side effects, is of broad significance. Lee et al. move us a step closer to this important goal by identifying structural differences in the β1-adrenoceptor in complex with β-arrestin 1 versus a G protein-mimicking nanobody.
- Thomas Jefferson University United States
Models, Molecular, Single-Domain Antibodies, Receptors, G-Protein-Coupled, beta-Arrestin 1, Biomimetic Materials, Animals, Humans, Molecular Targeted Therapy, Receptors, Adrenergic, beta-1, Signal Transduction
Models, Molecular, Single-Domain Antibodies, Receptors, G-Protein-Coupled, beta-Arrestin 1, Biomimetic Materials, Animals, Humans, Molecular Targeted Therapy, Receptors, Adrenergic, beta-1, Signal Transduction
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