Substrate-Selective Enzyme Inhibitors

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 2019 English Publisher:Elsevier BVJournal:Trends in Pharmacological Sciences, volume 40, pages 716-718 (issn: 0165-6147,

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Authors: Qian, Chu; Tina, Chang; Alan, Saghatelian;

doi: 10.1016/j.tips.2019.07.009

pmid: 31383375

Substrate-Selective Enzyme Inhibitors

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Abstract

Enzymes with multiple substrates pose a unique challenge for drug development because of an increased potential for on-target side effects. Maianti and colleagues (Nat. Chem. Biol., 2019) identify novel exo-site inhibitors with abilities to alter the substrate-selectivity of insulin-degrading enzymes (IDE). Their work illuminates new therapeutic avenues for discovering small-molecule enzyme inhibitors and redefines our current understanding of drugging enzymes with multiple substrates.

Related Organizations

Salk Institute for Biological Studies
United States

Keywords

Insulin, Enzyme Inhibitors, Insulysin

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