The pathophysiology and pharmacology of hepcidin
Copyright policy )The pathophysiology and pharmacology of hepcidin
Inappropriate production of the iron-regulatory hormone hepcidin contributes to the pathogenesis of common iron disorders. Absolute or relative deficiency of hepcidin causes iron overload in hereditary hemochromatosis and iron-loading anemias. Elevated hepcidin causes iron restriction in inflammatory conditions including autoimmune disease, critical illness, some cancers, and chronic kidney disease. Multiple agents targeting hepcidin and its regulators are under development as novel therapeutics for iron disorders. This review summarizes hepcidin biology and discusses the current landscape for hepcidin-targeting therapeutic strategies.
- University of California, Los Angeles United States
- University of California United States
Iron Overload, Liver Disease, Iron, Anemia, Hematology, Biological Sciences, anemia, Medical and Health Sciences, Hepcidins, 2.1 Biological and endogenous factors, Animals, Humans, Pharmacology & Pharmacy, Aetiology, iron disorders, iron overload, Digestive Diseases, ferroportin
Iron Overload, Liver Disease, Iron, Anemia, Hematology, Biological Sciences, anemia, Medical and Health Sciences, Hepcidins, 2.1 Biological and endogenous factors, Animals, Humans, Pharmacology & Pharmacy, Aetiology, iron disorders, iron overload, Digestive Diseases, ferroportin
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