ACE2: from vasopeptidase to SARS virus receptor
Copyright policy )ACE2: from vasopeptidase to SARS virus receptor
The zinc metallopeptidase angiotensin-converting enzyme 2 (ACE2) is the only known human homologue of the key regulator of blood pressure angiotensin-converting enzyme (ACE). Since its discovery in 2000, ACE2 has been implicated in heart function, hypertension and diabetes, with its effects being mediated, in part, through its ability to convert angiotensin II to angiotensin-(1-7). Unexpectedly, ACE2 also serves as the cellular entry point for the severe acute respiratory syndrome (SARS) virus and the enzyme is therefore a prime target for pharmacological intervention on several disease fronts.
- University of Leeds United Kingdom
Peptide Hormones, Peptidyl-Dipeptidase A, Article, Isoenzymes, Severe acute respiratory syndrome-related coronavirus, Animals, Blood Vessels, Humans, Receptors, Virus, Peptide Hydrolases
Peptide Hormones, Peptidyl-Dipeptidase A, Article, Isoenzymes, Severe acute respiratory syndrome-related coronavirus, Animals, Blood Vessels, Humans, Receptors, Virus, Peptide Hydrolases
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).489 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 0.1% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 1% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!