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Autophagy in Neuronal Development and Plasticity

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 2020Embargo end date: 14 Jul 2020 United Kingdom English Publisher:Elsevier BVJournal:Trends in Neurosciences, volume 43, pages 767-779 (issn: 0166-2236,

Authors: Fleming, Angeleen; Rubinsztein, David C;

doi: 10.1016/j.tins.2020.07.003 , 10.17863/cam.55060

pmid: 32800535

Autophagy in Neuronal Development and Plasticity

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Abstract

Autophagy is a highly conserved intracellular clearance pathway in which cytoplasmic contents are trafficked to the lysosome for degradation. Within neurons, it helps to remove damaged organelles and misfolded or aggregated proteins and has therefore been the subject of intense research in relation to neurodegenerative disease. However, far less is understood about the role of autophagy in other aspects of neuronal physiology. Here we review the literature on the role of autophagy in maintaining neuronal stem cells and in neuronal plasticity in adult life and we discuss how these contribute to structural and functional deficits observed in a range of human disorders.

Country

United Kingdom

Related Organizations

UK Dementia Research Institute
United Kingdom
University of Cambridge
United Kingdom

Keywords

Neurons, autophagy, Neuronal Plasticity, psychiatric disease, Neurodegenerative Diseases, memory, neurogenesis, neuronal stem cell (NSC), plasticity, Autophagy, Humans, Lysosomes

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	66
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 1%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 1%