
Enteric pathogens must overcome host microbiota-mediated colonization resistance to colonize the gut. Radlinski et al. discovered that Salmonella invasion of the small intestine leads to amino acid malabsorption. This increases amino acid availability in the large intestine, fueling Salmonella colonization through amino acid decarboxylation and counteracting SCFA-mediated cytoplasmic acidification.
Salmonella, Intestine, Small, Salmonella Infections, Humans, Animals, Intestine, Large, Amino Acids, Gastrointestinal Microbiome
Salmonella, Intestine, Small, Salmonella Infections, Humans, Animals, Intestine, Large, Amino Acids, Gastrointestinal Microbiome
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