Carriage of Colibactin-producing Bacteria and Colorectal Cancer Risk

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 2020 English Publisher:Elsevier BVJournal:Trends in Microbiology, volume 28, pages 874-876 (issn: 0966-842X,

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Authors: Vadim Dubinsky; Iris Dotan; Uri Gophna;

doi: 10.1016/j.tim.2020.05.015

pmid: 32507544

Carriage of Colibactin-producing Bacteria and Colorectal Cancer Risk

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Abstract

Colibactin is a genotoxic molecule, produced primarily by Escherichia coli. Colibactin causes DNA damage that may lead to colorectal cancer. Here we review recent advances in the study of colibactin and propose a focus on patients with inflammatory bowel diseases (IBD) who have higher levels of colibactin-producing bacteria in their intestines.

Related Organizations

Tel Aviv University
Israel
Rabin Medical Center
Israel

Keywords

Polyketides, Escherichia coli, Animals, Humans, Colorectal Neoplasms, Peptides, Escherichia coli Infections, DNA Damage

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