The Helicobacter pylori Cag Type IV Secretion System

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 2020 English Publisher:Elsevier BVJournal:Trends in Microbiology, volume 28, pages 682-695 (issn: 0966-842X,

Copyright policy )Funded by:NIH | Type IV protein secretion..., NIH | EGFR Activation in H. Pyl..., NIH | Pathogenesis of Helicobac... +1 projects

Authors: Timothy L, Cover; D Borden, Lacy; Melanie D, Ohi;

doi: 10.1016/j.tim.2020.02.004

pmid: 32451226

pmc: PMC7363556

The Helicobacter pylori Cag Type IV Secretion System

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Abstract

Colonization of the human stomach with Helicobacter pylori strains containing the cag pathogenicity island is a risk factor for development of gastric cancer. The cag pathogenicity island contains genes encoding a secreted effector protein (CagA) and components of a type IV secretion system (Cag T4SS). The molecular architecture of the H. pylori Cag T4SS is substantially more complex than that of prototype T4SSs in other bacterial species. In this review, we discuss recent discoveries pertaining to the structure and function of the Cag T4SS and its role in gastric cancer pathogenesis.

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Keywords

Antigens, Bacterial, Genomic Islands, Helicobacter pylori, Protein Conformation, Stomach, Helicobacter Infections, Type IV Secretion Systems, Mice, Bacterial Proteins, Stomach Neoplasms, Animals, Humans

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