Effects of PRRSV Infection on the Porcine Thymus

descriptionPublicationkeyboard_double_arrow_right Article 01 Mar 2020 English Publisher:Elsevier BVJournal:Trends in Microbiology, volume 28, pages 212-223 (issn: 0966-842X,

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Authors: Gang, Wang; Ying, Yu; Xuehui, Cai; En-Min, Zhou; Jeffrey J, Zimmerman;

doi: 10.1016/j.tim.2019.10.009

pmid: 31744664

Effects of PRRSV Infection on the Porcine Thymus

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Abstract

Porcine reproductive and respiratory syndrome virus (PRRSV) dramatically affects the thymus and its ability to carry out its normal functions. In particular, infection incapacitates PRRSV-susceptible CD14pos antigen-presenting cells (APCs) in the thymus and throughout the body. PRRSV-induced autophagy in thymic epithelial cells modulates the development of T cells, and PRRSV-induced apoptosis in CD4posCD8pos thymocytes modulates cellular immunity against PRRSV and other pathogens. Pigs are less able to resist and/or eliminate secondary infectious agents due the effect of PRRSV on the thymus, and this susceptibility phenomenon is long recognized as a primary characteristic of PRRSV infection.

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Keywords

Immunity, Cellular, Swine, Macrophages, T-Lymphocytes, Porcine Reproductive and Respiratory Syndrome, Thymus Gland, Autophagy, Animals, Porcine respiratory and reproductive syndrome virus, Disease Susceptibility

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