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Trends in Microbiology
Article . 2019 . Peer-reviewed
License: CC BY NC ND
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Trends in Microbiology
Article
License: CC BY NC ND
Data sources: UnpayWall
https://pubmed.ncbi.nlm.nih.go...
Article . 2020
Data sources: Europe PubMed Central
https://dx.doi.org/10.1016/j.t...
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Resistance Reversed in KatG Mutants of Mycobacterium tuberculosis

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 2019 English Publisher:Elsevier BVJournal:Trends in Microbiology, volume 27, pages 655-656 (issn: 0966-842X, Copyright policy )
Authors: Pablo, Machado; Cristiano Valim, Bizarro; Luiz Augusto, Basso;

doi: 10.1016/j.tim.2019.05.008

pmid: 31176512

Resistance Reversed in KatG Mutants of Mycobacterium tuberculosis

Abstract

A peptidomimetic containing a thiazolo ring-fused 2-pyridone (C10) has now been reported to inhibit hypoxia-induced tolerance to isoniazid (INH) in Mycobacterium tuberculosis (Flentie et al., Proc. Natl. Acad. Sci. U. S. A., 2019). The C10 compound could also potentiate the bactericidal activity in aerobically grown bacilli, prevented selection of drug-resistant strains, and reversed INH resistance in katG (catalase-peroxidase) mutants.

Related Organizations
Keywords

Bacterial Proteins, Drug Resistance, Bacterial, Isoniazid, Mycobacterium tuberculosis, Catalase

  • BIP!
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    selected citations
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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 7
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
7
Top 10%
Average
Average
hybrid