Unravelling HIV-1 Latency, One Cell at a Time
Copyright policy )Unravelling HIV-1 Latency, One Cell at a Time
A single virus is capable of infecting and replicating in a single cell. Recent advances across single-cell omics technologies - genomics, epigenomics, transcriptomics, epitranscriptomics, proteomics, and metabolomics - will offer unprecedented opportunities to gain more insights into the various aspects of the life cycle of viruses and their impact on the host cell. Here, using the human immunodeficiency virus type 1 (HIV-1) as an example, we summarize the current knowledge and the future potential of single-cell omics in the investigation of an important aspect of the life cycle of HIV-1 that represents a major hurdle in achieving viral eradication, HIV-1 latency.
- Institute of Microbiology Switzerland
- University of Lausanne Switzerland
- University Hospital of Lausanne Switzerland
- Hôpital de Sion Switzerland
- University of Zurich Switzerland
2404 Microbiology, HIV, 610 Medicine & health, HIV Infections, 2725 Infectious Diseases, cell omics, Genomics, 1 integration sites, 2726 Microbiology (medical), Virus Latency, 10234 Clinic for Infectious Diseases, human immunodeficiency virus type 1, viral latency, Host-Pathogen Interactions, 2406 Virology, HIV-1, Humans, Metabolomics, Single-Cell Analysis, single
2404 Microbiology, HIV, 610 Medicine & health, HIV Infections, 2725 Infectious Diseases, cell omics, Genomics, 1 integration sites, 2726 Microbiology (medical), Virus Latency, 10234 Clinic for Infectious Diseases, human immunodeficiency virus type 1, viral latency, Host-Pathogen Interactions, 2406 Virology, HIV-1, Humans, Metabolomics, Single-Cell Analysis, single
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