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Trends in Microbiology
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Trends in Microbiology
Article . 2014 . Peer-reviewed
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The end of Nef's tether

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 2014 English Publisher:Elsevier BVJournal:Trends in Microbiology, volume 22, pages 662-664 (issn: 0966-842X, Copyright policy )
Authors: Ruth, Serra-Moreno;

doi: 10.1016/j.tim.2014.10.008

pmid: 25468793

pmc: PMC4258156

The end of Nef's tether

Abstract

Tetherin represents an important barrier for successful cross-species transmissions of primate lentiviruses. HIV-1 overcame this obstacle by using Vpu as a countermeasure. However, Kluge and collaborators now show that HIV-1 group O uses Nef to antagonize tetherin, and that this activity may have contributed to its spread in West-Central Africa.

Related Organizations
Keywords

Antigens, CD, HIV-1, Humans, nef Gene Products, Human Immunodeficiency Virus

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 4
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Average
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
4
Average
Average
Average
bronze