In vivo protection by broadly neutralizing HIV antibodies

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Oct 2014 Netherlands English Publisher:Elsevier BVJournal:Trends in Microbiology, volume 22, pages 550-551 (issn: 0966-842X,

Copyright policy )Funded by:EC | SHEV

Authors: Marit J. van Gils; Rogier W. Sanders;

doi: 10.1016/j.tim.2014.08.006

pmid: 25169020

In vivo protection by broadly neutralizing HIV antibodies

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Abstract

Passive immunization studies, including a recent one by Pegu et al., have repeatedly shown that HIV-specific broadly neutralizing antibodies (bnAbs) protect rhesus macaques from HIV acquisition. In vitro neutralization potency and in vivo protection correlate very strongly, supporting the quest for an HIV vaccine that induces potent bnAbs.

Country

Netherlands

Related Organizations

Amsterdam UMC, location AMC
Netherlands
University of Amsterdam
Netherlands
Amsterdam UMC
Netherlands
Cornell University
United States
Academic Medical Center - University of Amsterdam
Netherlands

Keywords

AIDS Vaccines, HIV-1, Immunization, Passive, Animals, Humans, HIV Infections, HIV Antibodies, Antibodies, Neutralizing, Macaca mulatta

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