Long-lived reservoirs of HIV-1

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 2014 English Publisher:Elsevier BVJournal:Trends in Microbiology, volume 22, pages 173-175 (issn: 0966-842X,

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Authors: Thomas D, Zaikos; Kathleen L, Collins;

doi: 10.1016/j.tim.2014.02.015

pmid: 24641995

pmc: PMC4048589

Long-lived reservoirs of HIV-1

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Abstract

HIV-1 persistence in long-lived cellular reservoirs remains a major barrier to a cure. In a recent Nature Medicine paper, Buzon et al. identify memory T cells with stem cell-like properties (TSCM) that harbor infectious provirus and that likely contribute to HIV-1 persistence.

Related Organizations

University of Michigan–Ann Arbor
United States
University of Michigan–Flint
United States

Keywords

CD4-Positive T-Lymphocytes, HIV-1, Humans, HIV Infections, Lymphoid Progenitor Cells, Phylogeny, Disease Reservoirs, Virus Latency

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