Upstream of the SOS response: figure out the trigger
Copyright policy )Upstream of the SOS response: figure out the trigger
The bacterial SOS regulon encodes a response to DNA damage that not only functions to relieve the incurred damage but also enhances adaptation through mutagenesis and the lateral spread of virulence factors. Recent papers have demonstrated that certain stimuli can indirectly generate the SOS-inducing signal by activation of endogenous DNA damage mechanisms rather than by direct DNA damage. We suggest that these endogenous triggers have been recruited by bacteria to enable adaptation to various types of stresses.
- KU Leuven Belgium
- Katholieke Universiteit Leuven Belgium
recombinational repair, EXPRESSION, chromosomes, Biochemistry & Molecular Biology, 3101 Biochemistry and cell biology, STRESS, Bacterial Toxins, INHIBITION, Bacterial Physiological Phenomena, Microbiology, stress, DNA-POLYMERASE-IV, Bacterial Proteins, CHROMOSOMES, 1108 Medical Microbiology, expression, dna-polymerase-iv, SOS Response, Genetics, induction, DAMAGE, Science & Technology, INDUCTION, Escherichia coli Proteins, DNA Restriction Enzymes, Adaptation, Physiological, inhibition, RECOMBINATIONAL REPAIR, 3107 Microbiology, ESCHERICHIA-COLI, escherichia-coli, damage, Life Sciences & Biomedicine, Protein Kinases, 0605 Microbiology, Signal Transduction, Transcription Factors
recombinational repair, EXPRESSION, chromosomes, Biochemistry & Molecular Biology, 3101 Biochemistry and cell biology, STRESS, Bacterial Toxins, INHIBITION, Bacterial Physiological Phenomena, Microbiology, stress, DNA-POLYMERASE-IV, Bacterial Proteins, CHROMOSOMES, 1108 Medical Microbiology, expression, dna-polymerase-iv, SOS Response, Genetics, induction, DAMAGE, Science & Technology, INDUCTION, Escherichia coli Proteins, DNA Restriction Enzymes, Adaptation, Physiological, inhibition, RECOMBINATIONAL REPAIR, 3107 Microbiology, ESCHERICHIA-COLI, escherichia-coli, damage, Life Sciences & Biomedicine, Protein Kinases, 0605 Microbiology, Signal Transduction, Transcription Factors
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