Brd4: tethering, segregation and beyond

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 2004 English Publisher:Elsevier BVJournal:Trends in Microbiology, volume 12, pages 527-529 (issn: 0966-842X,

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Authors: Alison A, McBride; Maria G, McPhillips; Jaquelline G, Oliveira;

doi: 10.1016/j.tim.2004.10.002

pmid: 15539109

Brd4: tethering, segregation and beyond

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Abstract

Papillomaviruses segregate their genomes in dividing cells by tethering them to mitotic chromosomes via the viral E2 protein. A recent report has shown that this interaction is mediated by the cellular bromodomain protein Brd4. This discovery provides new insight into the mechanism of viral genome segregation and raises many exciting questions about the regulation and nature of the interaction of this complex with mitotic chromosomes.

Related Organizations

National Institute of Allergy and Infectious Diseases
United States
National Institute of Health
Pakistan
National Institutes of Health
United States

Keywords

DNA-Binding Proteins, Viral Proteins, Chromosome Segregation, Animals, Mitosis, Virus Replication, Papillomaviridae, Chromosomes

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