Antibiotic-induced lateral transfer of antibiotic resistance

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 2004 English Publisher:Elsevier BVJournal:Trends in Microbiology, volume 12, pages 401-404 (issn: 0966-842X,

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Authors: P J, Hastings; Susan M, Rosenberg; Andrew, Slack;

doi: 10.1016/j.tim.2004.07.003

pmid: 15337159

Antibiotic-induced lateral transfer of antibiotic resistance

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Abstract

As do many temperate bacteriophages, integrating conjugative elements (ICEs) recruit the SOS DNA damage response to mobilize themselves from the bacterial chromosome and infect other cells. This transfers resistance to multiple antibiotics. Several commonly used antibiotics induce the SOS response, potentially hastening genetic change and the evolution to resistance of pathogenic populations. The use of such antibiotics should be reconsidered.

Related Organizations

Baylor College of Medicine
United States

Keywords

Bacteria, Gene Transfer, Horizontal, Genes, Bacterial, Drug Resistance, SOS Response, Genetics, Anti-Bacterial Agents, DNA Damage

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