The recent study of overt attention during complex scene viewing has emphasized explaining gaze behavior in terms of image properties and image salience independently of the viewer's intentions and understanding of the scene. In this Opinion article, I outline an alternative approach proposing that gaze control in natural scenes can be characterized as the result of knowledge-driven prediction. This view provides a theoretical context for integrating and unifying many of the disparate phenomena observed in active scene viewing, offers the potential for integrating the behavioral study of gaze with the neurobiological study of eye movements, and provides a theoretical framework for bridging gaze control and other related areas of perception and cognition at both computational and neurobiological levels of analysis.