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Rho GTPases operating at the Golgi complex: Implications for membrane traffic and cancer biology

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 2017Publisher:Elsevier BVJournal:Tissue and Cell, volume 49, pages 163-169 (issn: 0040-8166,

Authors: Maeve Long; Jeremy C. Simpson;

doi: 10.1016/j.tice.2016.09.007

pmid: 27720426

Rho GTPases operating at the Golgi complex: Implications for membrane traffic and cancer biology

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Abstract

The Golgi complex is the central unit of the secretory pathway, modifying, processing and sorting proteins and lipids to their correct cellular localisation. Changes to proteins at the Golgi complex can have deleterious effects on the function of this organelle, impeding trafficking routes through it, potentially resulting in disease. It is emerging that several Rho GTPase proteins, namely Cdc42, RhoBTB3, RhoA and RhoD are at least in part localised to the Golgi complex, and a number of studies have shown that dysregulation of their levels or activity can be associated with cellular changes which ultimately drive cancer progression. In this mini-review we highlight some of the recent work that explores links between form and function of the Golgi complex, Rho GTPases and cancer.

Related Organizations

University College Dublin
Ireland

Keywords

rho GTP-Binding Proteins, Protein Transport, Neoplasms, Golgi Apparatus, Humans, Membrane Proteins, cdc42 GTP-Binding Protein, rhoA GTP-Binding Protein

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	19
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%