Activation and Regulation of Cytoplasmic Dynein
Copyright policy )Activation and Regulation of Cytoplasmic Dynein
Cytoplasmic dynein is an AAA+ motor that drives the transport of many intracellular cargoes towards the minus end of microtubules (MTs). Previous in vitro studies characterized isolated dynein as an exceptionally weak motor that moves slowly and diffuses on an MT. Recent studies altered this view by demonstrating that dynein remains in an autoinhibited conformation on its own, and processive motility is activated when it forms a ternary complex with dynactin and a cargo adaptor. This complex assembles more efficiently in the presence of Lis1, providing an explanation for why Lis1 is a required cofactor for most cytoplasmic dynein-driven processes in cells. This review describes how dynein motility is activated and regulated by cargo adaptors and accessory proteins.
- University of California, San Francisco United States
- University of California, Berkeley United States
- Physics Department United States
- University of California at Berkeley, Department of Molecular and Cell Biology United States
intracellular transport, Cytoplasmic Dyneins, 1.1 Normal biological development and functioning, Medical and Health Sciences, Rare Diseases, cargo adaptors, Underpinning research, dynactin, Medicinal and biomolecular chemistry, 2.1 Biological and endogenous factors, Medical biochemistry and metabolomics, Animals, Humans, Aetiology, dynein, motor proteins, Cryoelectron Microscopy, cytoskeleton, Biological Sciences, Single Molecule Imaging, Lis1, Biochemistry and cell biology, Chemical Sciences, Generic health relevance, Biochemistry and Cell Biology, Developmental Biology
intracellular transport, Cytoplasmic Dyneins, 1.1 Normal biological development and functioning, Medical and Health Sciences, Rare Diseases, cargo adaptors, Underpinning research, dynactin, Medicinal and biomolecular chemistry, 2.1 Biological and endogenous factors, Medical biochemistry and metabolomics, Animals, Humans, Aetiology, dynein, motor proteins, Cryoelectron Microscopy, cytoskeleton, Biological Sciences, Single Molecule Imaging, Lis1, Biochemistry and cell biology, Chemical Sciences, Generic health relevance, Biochemistry and Cell Biology, Developmental Biology
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