Stereoselective cyanation of 4-formyl and 4-imino-?-lactams: application to the synthesis of polyfunctionalized ?-lactams

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 2012 Spain English Publisher:Elsevier BVJournal:Tetrahedron, volume 68, pages 10,761-10,768 (issn: 0040-4020,

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Authors: Alcaide, Benito; Almendros, Pedro; Cabrero, Gema; Ruiz, M. Pilar;

doi: 10.1016/j.tet.2012.02.062

handle: 10261/80960

Stereoselective cyanation of 4-formyl and 4-imino-?-lactams: application to the synthesis of polyfunctionalized ?-lactams

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Abstract

The stereoselective reaction of 4-oxoazetidine-2-carbaldehydes and their corresponding imines with cyanide-based reagents give Î²-lactam Î±-aminonitriles, which are chameleonic building blocks for the controlled synthesis of a variety of new compounds including functionalized Î³-lactams, succinimide derivatives, and diamino-lactams derivatives in optically pure form. Â© 2012 Elsevier Ltd. All rights reserved.

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Spain

Related Organizations

Spanish National Research Council
Spain
Complutense University of Madrid
Spain
Instituto de Química Orgánica General
Spain

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