A structure–activity relationship study of brusatol, an antitumor quassinoid

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 2006 English Publisher:Elsevier BVJournal:Tetrahedron, volume 62, pages 4,262-4,271 (issn: 0040-4020,

Copyright policy )

Authors: Yukio Hitotsuyanagi; Ik Hwi Kim; Tomoyo Hasuda; Yuka Yamauchi; Koichi Takeya;

doi: 10.1016/j.tet.2006.01.083

A structure–activity relationship study of brusatol, an antitumor quassinoid

- Summary
- Metrics

Abstract

Abstract Analogues of brusatol ( 2 ) were prepared and examined for their cytotoxic activity by using P-388 murine leukemia cells. The following structure–activity relationships were noted: (i) an enone carbonyl oxygen or an enolic oxygen at C-2 is essential, but an oxygen at C-3 not essential for the activity; (ii) the C-11 β-hydroxyl group is important for the activity; and (iii) the length of the ester alkoxy side chain at C-21 seems to have a slight effect on the activity.

Related Organizations

Tokyo University of Pharmacy and Life Sciences
Japan
University of Tokyo
Japan

Impact byBIP!

	selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	26
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average