Copernicus Revisited: Overturning Ptolemy's View of the GPER Universe

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 2015 English Publisher:Elsevier BVJournal:Trends in Endocrinology & Metabolism, volume 26, pages 592-594 (issn: 1043-2760,

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Authors: Ross D, Feldman; Lee E, Limbird;

doi: 10.1016/j.tem.2015.09.002

pmid: 26482875

Copernicus Revisited: Overturning Ptolemy's View of the GPER Universe

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Abstract

Whether aldosterone activates the G-protein-coupled estrogen receptor (GPER) has been questioned, recently, in the name of Copernicus. However, for G-protein-coupled receptors (GPCRs) multiple hormone activators are common. Further, studies in mineralocorticoid receptor (MR)-deficient systems, with pharmacological GPER-selective antagonists or regulation of GPER expression, consistently show that some aldosterone effects can be GPER mediated.

Related Organizations

Memorial University of Newfoundland
Canada
Fisk University
United States

Keywords

Receptors, Estrogen, Humans, Aldosterone, Receptors, G-Protein-Coupled

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