The Nucleolus as a Proteostasis Regulator
Copyright policy )The Nucleolus as a Proteostasis Regulator
Protein misfolding is linked to disease, so how do mammalian cells cope with the burden of misfolded proteins in the nucleus? A recent study in Science (Frottin et al., 2019) demonstrated that on proteotoxic stress, the nucleolus could store some misfolded proteins for refolding or degradation.
- Tel Aviv University Israel
Protein Folding, Neurodegenerative Diseases, Protein Aggregation, Pathological, Amyloid beta-Protein Precursor, Proteostasis, Animals, Humans, HSP70 Heat-Shock Proteins, Proteostasis Deficiencies, Cell Nucleolus, Molecular Chaperones
Protein Folding, Neurodegenerative Diseases, Protein Aggregation, Pathological, Amyloid beta-Protein Precursor, Proteostasis, Animals, Humans, HSP70 Heat-Shock Proteins, Proteostasis Deficiencies, Cell Nucleolus, Molecular Chaperones
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