β-Catenin-Independent Roles of Wnt/LRP6 Signaling

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 2016 English Publisher:Elsevier BVJournal:Trends in Cell Biology, volume 26, pages 956-967 (issn: 0962-8924,

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Authors: Sergio P, Acebron; Christof, Niehrs;

doi: 10.1016/j.tcb.2016.07.009

pmid: 27568239

β-Catenin-Independent Roles of Wnt/LRP6 Signaling

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Abstract

Wnt/LRP6 signaling is best known for the β-catenin-dependent regulation of target genes. However, pathway branches have recently emerged, including Wnt/STOP signaling, which act independently of β-catenin and transcription. We review here the molecular mechanisms underlying β-catenin-independent Wnt/LRP6 signaling cascades and their implications for cell biology, development, and physiology.

Related Organizations

Heidelberg University
Germany
Institute of Molecular Biology
Germany

Keywords

Protein Stability, Low Density Lipoprotein Receptor-Related Protein-6, Animals, Humans, Receptor Cross-Talk, Models, Biological, Wnt Signaling Pathway, beta Catenin

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