The Taming of the TAMs
Copyright policy )The Taming of the TAMs
Tumor-associated macrophages and microglia (TAMs) are considered crucial elements in cancer progression. Recent work reveals the molecular mechanisms underlying acquired resistance to colony-stimulating factor-1 receptor (CSF-1R) inhibitors in glioblastoma (GBM) and shows that targeting TAMs with CSF-1R inhibitors leads to an antitumor response in GBM followed by the acquisition of resistance to treatment through the induction of insulin-like growth factor 1 (IGF-1) expression in TAMs.
- Vall d'Hebron Institute of Oncology (VHIO) Spain
- Hebron University Palestinian-administered areas
- Vall d'Hebron Hospital Universitari Spain
- Institució Catalana de Recerca i Estudis Avançats Spain
Phosphatidylinositol 3-Kinases, Macrophages, Neoplasms, Tumor Microenvironment, Animals, Humans, Receptor, Macrophage Colony-Stimulating Factor, Microglia, Glioblastoma, Signal Transduction
Phosphatidylinositol 3-Kinases, Macrophages, Neoplasms, Tumor Microenvironment, Animals, Humans, Receptor, Macrophage Colony-Stimulating Factor, Microglia, Glioblastoma, Signal Transduction
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