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Trends in Cell Biology
Article . 2016 . Peer-reviewed
License: Elsevier TDM
Data sources: Crossref
https://pubmed.ncbi.nlm.nih.go...
Article . 2017
Data sources: Europe PubMed Central
https://dx.doi.org/10.1016/j.t...
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Mitochondrial UPR: A Double-Edged Sword

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 2016 English Publisher:Elsevier BVJournal:Trends in Cell Biology, volume 26, pages 563-565 (issn: 0962-8924, Copyright policy )
Authors: Ye, Tian; Carsten, Merkwirth; Andrew, Dillin;

doi: 10.1016/j.tcb.2016.06.006

pmid: 27394966

Mitochondrial UPR: A Double-Edged Sword

Abstract

The mitochondrial unfolded protein response (UPR(mt)) promotes the recovery of dysfunctional mitochondria. Surprisingly, UPR(mt) activation inadvertently maintains and propagates the deleterious mtDNA in a heteroplasmic Caenorhabditis elegans strain, with detrimental consequences. This study extends our understanding of the UPR(mt) and provides a possible therapeutic target for diseases associated with mtDNA mutations.

Related Organizations
Keywords

Unfolded Protein Response, Animals, Humans, Caenorhabditis elegans, DNA, Mitochondrial, Models, Biological, Oxidative Phosphorylation, Mitochondria

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    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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    influence
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
45
Top 10%
Top 10%
Top 10%
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