Brd4 is on the move during inflammation
Copyright policy )Brd4 is on the move during inflammation
Enhancer landscapes are shaped by the integrated functions of lineage-specific and signal-dependent transcription factors. A new study by Brown et al. suggests that the signal-dependent transcription factor NF-kB can modulate global enhancer activities by altering the occupancy of Brd4, a BET bromodomain coactivator protein, across the genome. This work reveals new principles of enhancer dynamics and insights into the therapeutic modulation of enhancer function with BET bromodomain inhibitors.
- Stony Brook University United States
- Cold Spring Harbor Laboratory United States
Inflammation, Transcription Factor RelA, Animals, Humans, NF-kappa B p50 Subunit, Nuclear Proteins, Atherosclerosis, Transcription Factors
Inflammation, Transcription Factor RelA, Animals, Humans, NF-kappa B p50 Subunit, Nuclear Proteins, Atherosclerosis, Transcription Factors
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