Endosomal and non-endosomal functions of ESCRT proteins
Copyright policy )Endosomal and non-endosomal functions of ESCRT proteins
The three endosomal sorting complexes required for transport (ESCRTs) are integral to the degradation of endocytosed membrane proteins and multivesicular body (MVB) biogenesis. Here, we review evidence that ESCRTs have evolved as a specialized machinery for the degradative sorting of ubiquitinated membrane proteins and we highlight recent studies that have shed light on the mechanisms by which these complexes mediate protein sorting, MVB biogenesis, tumour suppression and viral budding. We also discuss evidence that some ESCRT subunits have evolved additional functions that are unrelated to membrane trafficking.
- University of Oslo Norway
Endosomal Sorting Complexes Required for Transport, Ubiquitin, Tumor Suppressor Proteins, Vesicular Transport Proteins, Endosomes, Models, Biological, DNA-Binding Proteins, Evolution, Molecular, Protein Transport, Tsg101 Protein, Multiprotein Complexes, Animals, Humans, Transport Vesicles, Protein Processing, Post-Translational, Transcription Factors, Virus Physiological Phenomena
Endosomal Sorting Complexes Required for Transport, Ubiquitin, Tumor Suppressor Proteins, Vesicular Transport Proteins, Endosomes, Models, Biological, DNA-Binding Proteins, Evolution, Molecular, Protein Transport, Tsg101 Protein, Multiprotein Complexes, Animals, Humans, Transport Vesicles, Protein Processing, Post-Translational, Transcription Factors, Virus Physiological Phenomena
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