Bub1 and the multilayered inhibition of Cdc20–APC/C in mitosis
Copyright policy )Bub1 and the multilayered inhibition of Cdc20–APC/C in mitosis
To ensure the accuracy of chromosome segregation in mitosis, the spindle checkpoint blocks the activity of the anaphase-promoting complex APC/C until all chromosomes are properly bi-orientated on the metaphase spindle. How the checkpoint machinery actually inhibits the APC/C is still unclear. A new paper by Tang and coworkers helps further our understanding of this complex and fundamental process.
- Ecole Normale Supérieure de Lyon France
- Wellcome Trust United Kingdom
- University of Edinburgh United Kingdom
- University of Lyon System France
- Wellcome Centre for Cell Biology United Kingdom
Saccharomyces cerevisiae Proteins, Sequence Homology, Amino Acid, Cdc20 Proteins, Molecular Sequence Data, Mitosis, Ubiquitin-Protein Ligase Complexes, Cell Cycle Proteins, Protein Serine-Threonine Kinases, Anaphase-Promoting Complex-Cyclosome, [SDV.BC.BC] Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], Animals, Humans, Amino Acid Sequence, Schizosaccharomyces pombe Proteins, Phosphorylation, Protein Kinases
Saccharomyces cerevisiae Proteins, Sequence Homology, Amino Acid, Cdc20 Proteins, Molecular Sequence Data, Mitosis, Ubiquitin-Protein Ligase Complexes, Cell Cycle Proteins, Protein Serine-Threonine Kinases, Anaphase-Promoting Complex-Cyclosome, [SDV.BC.BC] Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], Animals, Humans, Amino Acid Sequence, Schizosaccharomyces pombe Proteins, Phosphorylation, Protein Kinases
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