How IGF-II Binds to the Human Type 1 Insulin-like Growth Factor Receptor
Copyright policy )How IGF-II Binds to the Human Type 1 Insulin-like Growth Factor Receptor
Human type 1 insulin-like growth factor receptor (IGF-1R) signals chiefly in response to the binding of insulin-like growth factor I. Relatively little is known about the role of insulin-like growth factor II signaling via IGF-1R, despite the affinity of insulin-like growth factor II for IGF-1R being within an order of magnitude of that of insulin-like growth factor I. Here, we describe the cryoelectron microscopy structure of insulin-like growth factor II bound to a leucine-zipper-stabilized IGF-1R ectodomain, determined in two conformations to a maximum average resolution of 3.2 Å. The two conformations differ in the relative separation of their respective points of membrane entry, and comparison with the structure of insulin-like growth factor I bound to IGF-1R reveals long-suspected differences in the way in which the critical C domain of the respective growth factors interact with IGF-1R.
- Monash University Australia
- Flinders University Australia
- Wellcome Trust United Kingdom
- Walter and Eliza Hall Institute of Medical Research Australia
- Monash University, Clayton campus Australia
570, single-particle 3D reconstruction, Binding Sites, Cryoelectron Microscopy, cryoelectron microscopy, type 1 insulin-like growth factor receptor, insulin-like growth factor I, 3T3 Cells, CHO Cells, leucine zipper, Article, 620, Receptor, IGF Type 1, Molecular Docking Simulation, Mice, Cricetulus, insulin-like growth factor II, Insulin-Like Growth Factor II, Cricetinae, Animals, Humans, Protein Binding
570, single-particle 3D reconstruction, Binding Sites, Cryoelectron Microscopy, cryoelectron microscopy, type 1 insulin-like growth factor receptor, insulin-like growth factor I, 3T3 Cells, CHO Cells, leucine zipper, Article, 620, Receptor, IGF Type 1, Molecular Docking Simulation, Mice, Cricetulus, insulin-like growth factor II, Insulin-Like Growth Factor II, Cricetinae, Animals, Humans, Protein Binding
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