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Structure
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Structure
Article . 2017 . Peer-reviewed
License: Elsevier Non-Commercial
Data sources: Crossref
Structure
Article . 2019
Data sources: Europe PubMed Central
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Remodeling KRAS

descriptionPublicationkeyboard_double_arrow_right Article 01 Sep 2017 English Publisher:Elsevier BVJournal:Structure, volume 25, pages 1,323-1,324 (issn: 0969-2126, Copyright policy )
Authors: Daniel J, Deredge; Patrick L, Wintrode;

doi: 10.1016/j.str.2017.08.012

pmid: 28877504

Remodeling KRAS

Abstract

Mutations in members of the RAS family of small GTPases have been associated with numerous human cancers. However, RAS family members are notoriously difficult to target. In this issue of Structure, Lu et al. (2017) examine the effects of two compounds with distinct chemical scaffolds on the structure and dynamics of an oncogenic KRAS mutant, thus highlighting the usefulness of HDX-MS for drug development.

Related Organizations
Keywords

Proto-Oncogene Proteins p21(ras), Mutation, ras Proteins, Humans, Deuterium, Mass Spectrometry, Hydrogen

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
hybrid
Related to Research communities
Cancer Research