Exposing the Molecular Machinery of BK Polyomavirus

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 2016 English Publisher:Elsevier BVJournal:Structure, volume 24, page 495 (issn: 0969-2126,

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Authors: Christopher B, Buck;

doi: 10.1016/j.str.2016.03.011

pmid: 27050683

pmc: PMC6289593

Exposing the Molecular Machinery of BK Polyomavirus

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Abstract

BK polyomavirus (BKV) is an opportunistic pathogen that poses a serious threat to organ transplant recipients. In this issue of Structure, Hurdiss and colleagues' (Hurdiss et al., 2016) beautiful new high-resolution cryo-EM reconstruction of BKV provides a structural roadmap for the ongoing development of therapeutic antibodies and vaccines targeting this potentially deadly virus. The study also serves as a platform for exploring the basic biology of virion assembly and infectious entry.

Related Organizations

National Cancer Institute
United States
Center for Cancer Research
United States

Keywords

Models, Molecular, Polyomavirus Infections, BK Virus, Kidney Transplantation

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