Basis of Cargo Recognition by Importin αs: The Power of Structure
Copyright policy )Basis of Cargo Recognition by Importin αs: The Power of Structure
In this issue of Structure, Pumroy and colleagues have solved the crystal structure of the influenza virus polymerase PB2 C-terminal domain complexed with different Importin αs. Combining molecular dynamics with structural and biochemical data, the so-far elusive basis for selectivity of binding to distinct different importin αs is beginning to become accessible.
- University of Padua Italy
- Monash University Australia
- Monash University, Clayton campus Australia
Cell Nucleus, Models, Molecular, alpha Karyopherins, Nuclear Localization Signals, nuclear transport, RNA-Dependent RNA Polymerase, Evolution, Molecular, Viral Proteins, Structural Biology, Humans, Molecular Biology
Cell Nucleus, Models, Molecular, alpha Karyopherins, Nuclear Localization Signals, nuclear transport, RNA-Dependent RNA Polymerase, Evolution, Molecular, Viral Proteins, Structural Biology, Humans, Molecular Biology
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