The HIV-1 Env Trimer in HD

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 2014 English Publisher:Elsevier BVJournal:Structure, volume 22, pages 935-936 (issn: 0969-2126,

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Authors: Munro, James B.; Mothes, Walther;

doi: 10.1016/j.str.2014.06.004

pmid: 25007222

pmc: PMC4094347

The HIV-1 Env Trimer in HD

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Abstract

Understanding the structure of the native HIV-1 envelope spike protein is critical for the development of vaccines and antiviral therapies. In this issue of Structure, Guttman and colleagues use hydrogen-deuterium exchange (HDX) to provide new insights into the structure of the HIV-1 Env trimer and enhance our understanding of how HIV-1 Env is activated for virus fusion.

Related Organizations

Technical University of Munich
Germany
TECHNISCHE UNIVERSITAET MUENCHEN
Germany
Yale University
United States
Ilmenau University of Technology
Germany

Keywords

Structural Biology, CD4 Antigens, env Gene Products, Human Immunodeficiency Virus, Humans, Protein Multimerization, Protein Structure, Quaternary, Molecular Biology

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