Deposition Diseases and 3D Domain Swapping
Copyright policy )Deposition Diseases and 3D Domain Swapping
Protein aggregation is a feature of both normal cellular assemblies and pathological protein depositions. Although the limited order of aggregates has often impeded their structural characterization, 3D domain swapping has been implicated in the formation of several protein aggregates. Here, we review known structures displaying 3D domain swapping in the context of amyloid and related fibrils, prion proteins, and macroscopic aggregates, and we discuss the possible involvement of domain swapping in protein deposition diseases.
- University of California, Los Angeles United States
- Howard Hughes Medical Institute United States
Amyloid, Protein Folding, Crystallography, PROTEINS, Protein Conformation, HUMDISEASE, Amyloidosis, Metabolic Diseases, Structural Biology, Humans, Molecular Biology
Amyloid, Protein Folding, Crystallography, PROTEINS, Protein Conformation, HUMDISEASE, Amyloidosis, Metabolic Diseases, Structural Biology, Humans, Molecular Biology
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