
pmid: 34624226
How master regulators such as Oct4 can shape 3D genome architecture during cell reprogramming remains poorly understood. In this issue of Cell Stem Cell, Wang et al. (2021) demonstrate that Oct4 undergoes phase separation to reconfigure TAD architecture for cell fate control.
Genome, Cell Differentiation, Cellular Reprogramming, Octamer Transcription Factor-3
Genome, Cell Differentiation, Cellular Reprogramming, Octamer Transcription Factor-3
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