Neutrophil elastase: Nonsense lost in translation

descriptionPublicationkeyboard_double_arrow_right Article 01 May 2021 English Publisher:Elsevier BVJournal:Cell Stem Cell, volume 28, pages 790-792 (issn: 1934-5909,

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Authors: Marshall S. Horwitz;

doi: 10.1016/j.stem.2021.04.007

pmid: 33961760

Neutrophil elastase: Nonsense lost in translation

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Abstract

In this issue of Cell Stem Cell, Daniel Bauer and colleagues investigate the pathogenesis of ELANE-associated severe congenital neutropenia (SCN) and describe two potentially universal gene correction strategies for autosomal dominant disorders (Rao et al., 2021). One exploits nonsense-mediated decay to prevent translation of the mutant allele. The other unexpectedly blocks translation by shortening the 3'-UTR.

Related Organizations

University of Washington
United States
Institute for Stem Cell Biology and Regenerative Medicine
United States
University of Mary
United States

Keywords

Gene Editing, Neutropenia, Virulence, Mutation, Humans, Leukocyte Elastase

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