Mononuclear Diploidy at the Heart of Cardiomyocyte Proliferation

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Oct 2017 Netherlands English Publisher:Elsevier BVJournal:Cell Stem Cell, volume 21, pages 421-422 (issn: 1934-5909,

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Authors: da Costa Martins, Paula A.;

doi: 10.1016/j.stem.2017.09.012

pmid: 28985522

Mononuclear Diploidy at the Heart of Cardiomyocyte Proliferation

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Abstract

Reporting in Nature Genetics, Patterson et al. (2017) show that adult mammalian hearts possess an innate capacity to regenerate, which depends on a small population of mononuclear diploid cardiomyocytes. These cells undergo karyokinesis and cytokinesis, raising the possibility that endogenous cardiac muscle cells can be stimulated to proliferate for myocardial repair.

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Netherlands

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Keywords

Mice, CARDIAC REGENERATION, Myocardium, Animals, Regeneration, Heart, Myocytes, Cardiac, Diploidy, Cell Proliferation

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