Moving Toward the Ground State

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 2015 English Publisher:Elsevier BVJournal:Cell Stem Cell, volume 17, pages 375-376 (issn: 1934-5909,

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Authors: Kumar, Ishan; Ivanova, Natalia;

doi: 10.1016/j.stem.2015.09.009

pmid: 26431178

Moving Toward the Ground State

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Abstract

Transferring mouse ESCs to a media supplemented with Mek and Gsk3β inhibitors (2i) provokes marked transcriptional and epigenetic changes, embodying a shift toward ground-state pluripotency. In this issue of Cell Stem Cell, Kolodziejczyk et al. (2015) examine population structures of ESCs while Galonska et al. (2015) unravel the mechanisms underlying regulatory network rewiring during 2i-mediated reprogramming.

Related Organizations

Yale University
United States

Keywords

Genetics, Molecular Medicine, Animals, RNA, Mouse Embryonic Stem Cells, Cell Biology, Transcriptome, Epigenesis, Genetic

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