Ascl2 Reinforces Intestinal Stem Cell Identity

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 2015 English Publisher:Elsevier BVJournal:Cell Stem Cell, volume 16, pages 105-106 (issn: 1934-5909,

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Authors: Yan, Kelley S.; Kuo, Calvin J.;

doi: 10.1016/j.stem.2015.01.014

pmid: 25658363

Ascl2 Reinforces Intestinal Stem Cell Identity

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Abstract

Ascl2 is a Wnt-responsive master transcription factor that controls the Lgr5(+) intestinal stem cell gene expression program. Now in Cell Stem Cell, Schuijers et al. (2015) report an Ascl2 positive feedback loop, tuned by previous Wnt pathway activity, that perpetuates intestinal stem cell identity in response to Wnt/R-spondin stimulation.

Related Organizations

Stanford University
United States

Keywords

Basic Helix-Loop-Helix Proteins, Stem Cells, Genetics, Molecular Medicine, Animals, Cell Biology, Intestinal Mucosa, Thrombospondins, Wnt Signaling Pathway

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