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Cell Stem Cell
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Cell Stem Cell
Article . 2013
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Transplantable Liver Organoids Made from Only Three Ingredients

Authors: Willenbring, Holger; Soto-Gutierrez, Alejandro;

Transplantable Liver Organoids Made from Only Three Ingredients

Abstract

Liver cell therapies using induced pluripotent stem cells (iPSCs) are in development. A recent paper in Nature by Takebe et al. expands the range of liver diseases that could be treated with iPSC-derived hepatocytes by combining them with endothelial and stromal cells to generate organoids that survive and function extrahepatically.

Country
United States
Keywords

Biomedical and clinical sciences, 1.1 Normal biological development and functioning, Medical Biotechnology, Chronic Liver Disease and Cirrhosis, Induced Pluripotent Stem Cells, 610, Regenerative Medicine, Medical and Health Sciences, Oral and gastrointestinal, Genetics, 2.1 Biological and endogenous factors, Animals, Humans, Stem Cell Research - Induced Pluripotent Stem Cell - Non-Human, Biomedical and Clinical Sciences, Stem Cell Research - Induced Pluripotent Stem Cell, Stem Cell Research - Induced Pluripotent Stem Cell - Human, 5.2 Cellular and gene therapies, Liver Disease, Cell Biology, Biological Sciences, Stem Cell Research, Biological sciences, Good Health and Well Being, Liver, Molecular Medicine, Digestive Diseases, Developmental Biology

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    15
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Top 10%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
15
Top 10%
Average
Top 10%
Green
hybrid