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Stem Cell Aging and Aberrant Differentiation within the Niche

descriptionPublicationkeyboard_double_arrow_right Article 01 Jul 2009 English Publisher:Elsevier BVJournal:Cell Stem Cell, volume 5, pages 6-8 (issn: 1934-5909, Copyright policy )
Authors: Choi, Jinkuk; Artandi, Steven;

doi: 10.1016/j.stem.2009.06.006

pmid: 19570507

Stem Cell Aging and Aberrant Differentiation within the Niche

Abstract

Stem cells age, but the underlying mechanisms remain unclear. In a recent issue of Cell, Inomata and colleagues (2009) show that DNA damage, a prime suspect in stem cell aging, causes graying and loss of melanocyte stem cells by inducing premature differentiation, without inducing apoptosis or senescence.

Related Organizations
Keywords

Melanins, Stem Cells, Cell Differentiation, Cell Biology, Mice, Lac Operon, Genetics, Molecular Medicine, Animals, Melanocytes, Stem Cell Niche, Cellular Senescence, DNA Damage, Hair

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 23
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
23
Average
Top 10%
Top 10%
hybrid