
pmid: 18371441
Asymmetric stem cell division is thought to require precise orientation of the mitotic spindle. However, a recent study in Cell (Yingling et al., 2008) analyzes the role of LIS1 in the developing mouse brain and shows that spindle orientation is more important during early, symmetric progenitor cell divisions than for later asymmetric divisions.
Neuroepithelial Cells, Cell Division/physiology, Spindle Apparatus, Biochimie, biophysique & biologie moléculaire, Mice, Stem Cells/cytology/physiology, Genetics, Animals, Stem Cells, Brain, Cell Biology, Life sciences, Neuroepithelial Cells/cytology/physiology, Mitotic Spindle Apparatus/physiology, 1-Alkyl-2-acetylglycerophosphocholine Esterase, Microtubule-Associated Proteins/metabolism, Sciences du vivant, Molecular Medicine, 1-Alkyl-2-acetylglycerophosphocholine Esterase/metabolism, Brain/embryology, Microtubule-Associated Proteins, Cell Division, Biochemistry, biophysics & molecular biology
Neuroepithelial Cells, Cell Division/physiology, Spindle Apparatus, Biochimie, biophysique & biologie moléculaire, Mice, Stem Cells/cytology/physiology, Genetics, Animals, Stem Cells, Brain, Cell Biology, Life sciences, Neuroepithelial Cells/cytology/physiology, Mitotic Spindle Apparatus/physiology, 1-Alkyl-2-acetylglycerophosphocholine Esterase, Microtubule-Associated Proteins/metabolism, Sciences du vivant, Molecular Medicine, 1-Alkyl-2-acetylglycerophosphocholine Esterase/metabolism, Brain/embryology, Microtubule-Associated Proteins, Cell Division, Biochemistry, biophysics & molecular biology
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