To provide a brief overview of the development of monoclonal antibodies in immunotherapy, including a review of the mechanism of action and types, and indications for use.Peer-reviewed journal articles, book chapters, internet.Monoclonal antibodies offer alternative treatment to cancer patients who have failed or progressed on standard chemotherapy. Clinical research continues to explore new antigens to target in hopes of discovering the "magic bullet" to eliminate cancer altogether.Collaboration with infection control should be considered for nurses administering monoclonal antibodies to ensure their safe handling. These agents should be verified before administration with the two-RN sign-off system. Nurses play a vital role in providing adequate patient education to ensure patient safety.