Abstract Vrancea major intermediate-depth earthquakes produced extreme damage in Bucharest city, located at about 165 km epicenter distance. Our purpose is to investigate the influence of local geological conditions upon the seismic motion in Bucharest in case of large ( M >7) Vrancea earthquakes. Two input data sets are used: (a) geological, geotechnical and geophysical information, including in situ measurements, and (b) acceleration recordings of Vrancea earthquakes. Local response evaluation based on first dataset is confirmed by the spectral analysis of the earthquake records. Two main features are outlined: non-stationarity of ground motion dynamic amplification from one event to other and inadequacy of limiting the investigation depth to uppermost 30 m to evaluate ground dynamic characteristics. Consequently (1) we cannot extrapolate the ground motion response determined for moderate and small earthquakes to anticipate the effects of the large Vrancea shocks and (2) the local response is controlled by the entire package of Quaternary deposits which are significantly deeper than 30 m depth beneath Bucharest Area.