This article will define the concept of fetal/neonatal inflammatory response, and examine the complex interaction between inflammation and neurotoxicity. There appear to be important interactions between infection/inflammation and hypoxia-ischaemia leading to cytokine release and subsequent brain injury. This article will also define adverse outcome and summarize the complexities inherent to neurodevelopmental assessment. Finally, this article will investigate the currently available evidence suggesting a link between inflammatory response and adverse neurodevelopmental outcome, and focus on those variables that need further study: timing and nature of the infectious/inflammatory process; established and new anti-insult strategies; morbidity in organs other than the brain; genetic influences; and environmental factors.