The European tradition makes a sharp distinction between animism and science. On the basis of this distinction, either animism is reproved for failing to reach the heights of science, or science is reproved for failing to reach the heights of animism. In this essay, I draw on work in the history and philosophy and science, combined with a method from the sociology of scientific knowledge, to question the sharpness of this distinction. Along the way, I also take guidance from the research of North American Indigenous scholars. As it turns out, there is a rich, if largely overlooked, tradition of Aristotelian animism running through the history of modern European science, and this tradition sometimes resonates with Indigenous perspectives. By challenging the entrenched distinction between animism and science, I aim to help reconcile ongoing tensions between Indigenous and European scientific groups, and so strengthen prospects for their mutually beneficial cooperation.