Aquaporin 2 Mutations in Nephrogenic Diabetes Insipidus
Copyright policy )Aquaporin 2 Mutations in Nephrogenic Diabetes Insipidus
Water reabsorption in the renal collecting duct is regulated by the antidiuretic hormone vasopressin (AVP). When the vasopressin V2 receptor, present on the basolateral site of the renal principal cell, becomes activated by AVP, aquaporin-2 (AQP2) water channels will be inserted in the apical membrane, and in this fashion, water can be reabsorbed from the pro-urine into the interstitium. The essential role of the vasopressin V2 receptor and AQP2 in the maintenance of body water homeostasis became clear when it was shown that mutations in their genes cause nephrogenic diabetes insipidus, a disorder in which the kidney is unable to concentrate urine in response to AVP. This review describes the current knowledge on AQP2 mutations in nephrogenic diabetes insipidus.
- Radboud University Nijmegen Netherlands
- Radboud University Nijmegen Medical Centre Netherlands
Aquaporin 2, IGMD 9: Renal disorder, NCMLS 2: Metabolism, transport and motion, Diabetes Insipidus, Nephrogenic, Genes, Recessive, UMCN 5.4: Renal disorders, NCMLS 5: Membrane transport and intracellular motility, UMCN 5.1: Genetic defects of metabolism, Disease Models, Animal, Mice, Mutation, Animals, Humans, IGMD 5: Health aging / healthy living, Genes, Dominant
Aquaporin 2, IGMD 9: Renal disorder, NCMLS 2: Metabolism, transport and motion, Diabetes Insipidus, Nephrogenic, Genes, Recessive, UMCN 5.4: Renal disorders, NCMLS 5: Membrane transport and intracellular motility, UMCN 5.1: Genetic defects of metabolism, Disease Models, Animal, Mice, Mutation, Animals, Humans, IGMD 5: Health aging / healthy living, Genes, Dominant
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).82 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!